Back to search

Article

Temporally integrated transcriptome analysis reveals ASFV pathology and host response dynamics

2022-05-07

Abstract excerpt

African swine fever virus (ASFV) causes a lethal swine hemorrhagic disease and is currently responsible for widespread damage to the pig industry. The molecular mechanisms of ASFV pathogenicity and its interaction with host responses remain poorly understood. In this study, we profiled the temporal viral and host transcriptomes in porcine alveolar macrophages (PAMs) infected at 6, 12, 24 and 48 hours with highly v...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
a4257c2a-d74d-5890-a86b-5c8e7d6533ba
DOI
10.1101/2022.05.06.490987
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Temporally integrated transcriptome analysis reveals ASFV pathology and host response dynamicsDOI 10.1101/2022.05.06.490987
Mechanism of interaction between virus and host is inferred from the changes of gene expression in macrophages infected with African swine fever virus CN/GS/2018 strainSemantic proximity
Transcriptome profiles of organ tissues from pigs experimentally infected with African swine fever virus in early phase of infectionSemantic proximity
Temporal dynamics of cytokine, leukocyte, and whole blood transcriptome profiles of pigs infected with African swine fever virusSemantic proximity
Transcriptome profiling in swine macrophages infected with African swine fever virus at single-cell resolutionSemantic proximity
Characterization of the African Swine Fever Virus transcriptome and the associated innate immune response reveals key features of virulenceSemantic proximity
Transcriptome profile of spleen tissues from locally-adapted Kenyan pigs (Sus scrofa) experimentally infected with three varying doses of a highly virulent African swine fever virus genotype IX isolate: Ken12/busia.1 (Ken-1033)Semantic proximity
Functional characterization of African swine fever virus I329L gene by transcriptome analysis.Semantic proximity
Transcriptome profile of spleen tissues from locally-adapted Kenyan pigs (Sus scrofa) experimentally infected with three varying doses of a highly virulent African swine fever virus genotype IX isolate: Ken12/busia.1 (ken-1033).Semantic proximity
Transcriptome Profiling Reveals Features of Immune Response and Metabolism of Acutely Infected, Dead and Asymptomatic Infection of African Swine Fever Virus in PigsSemantic proximity
Infection of domestic pigs with a genotype II potent strain of ASFV causes cytokine storm and lymphocyte mass reduction.Semantic proximity
Comprehensive Characterization of the Genetic Landscape of African Swine Fever Virus: Insights into Infection Dynamics, Immunomodulation, Virulence and Genes with Unknown FunctionSemantic proximity
Evaluation of Pathogenetic and Immunological Parameters of the Genotype I and II Recombinant African Swine Fever Viruses Detected in Pigs in Vietnam.Semantic proximity
Select a neighboring publication to make it the new centre.