Back to search

Article

Herbal melanin modulates PGE2 and IL-6 gastroprotective markers through COX-2 and TLR4 signaling in the gastric cancer cell line AGS

2022-05-13

Abstract excerpt

We reported a gastric anti-ulcerogenic effect of the Nigella sativa (L.)-derived herbal melanin (HM) in rat models. However, the molecular mechanisms underlying the HM gastroprotective effect remain unknown. Cyclooxygenase-2 (COX-2)-catalyzed prostaglandin E2 (PGE2) and toll-like receptor 4 (TLR4)-mediated interleukin-6 (IL-6) production and secretion play major roles in gastric mucosal protection. In the current...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
a33241fe-0f5e-5497-be7d-9397c9c76f2f
DOI
10.21203/rs.3.rs-1597711/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Herbal melanin modulates PGE2 and IL-6 gastroprotective markers through COX-2 and TLR4 signaling in the gastric cancer cell line AGSDOI 10.21203/rs.3.rs-1597711/v1
Green walnut husk extracts Proliferation and Migration in Gastric CancerSemantic proximity
Wharton Jelly Stem Cells inhibits AGS Gastric Cancer Cells through Induction of Apoptosis and Modification of MAPK and NF‑κB Signaling PathwaysSemantic proximity
Metabolites Profiling and Bioassays Reveal Bassia indica Ethanol Extract Protective Effect against Stomach Ulcers Development via HMGB1/TLR-4/NF-κB PathwaySemantic proximity
Myricetin suppressed DSS-induced colitis and promoted the therapeutic success of Infliximab in TNBS-induced colitisSemantic proximity
(2E,6Z,10E)-7-hydroxymethyl-3,11,15-trimethyl-2,6,10,14-hexadecatetraen-1-ol (Plaunotol) increases cyclooxygenase-2 expression via nuclear factor kappaB and cyclic AMP response element in rat gastric epithelial cells.Semantic proximity
Exploring the effect of Weifuchun capsule on the toll-like receptor pathway mediated HES6 and immune regulation against chronic atrophic gastritisSemantic proximity
Xanthones from Gentianopsispaludosa(Hook. f.) Ma ameliorates colonic epithelial-mesenchymal transition through regulating autophagySemantic proximity
Anti-proliferative activity of Origanum vulgare inhibited lipogenesis and induced mitochondrial mediated apoptosis in human stomach cancer cell linesSemantic proximity
Dandelion root extracts and taraxasterol inhibit LPS‑induced colorectal cancer cell viability by blocking TLR4‑NFκB‑driven ACE2 and TMPRSS2 pathwaysSemantic proximity
Protective effect of silymarin nanoemulsion on 5-fluorouracil-induced gastrointestinal toxicity in ratsSemantic proximity
Polyunsaturated Fatty Acids ω-3 and ω-6 Regulate the Proliferation Invasion and Angiogenesis of Human Gastric Cancer Through COX/PGE Signaling PathwaySemantic proximity
Polysaccharides from Nostoc commune Vaucher activate macrophages via NF-κB and AKT/JNK1/2 pathways to suppress colorectal cancer growth in vivoSemantic proximity
Select a neighboring publication to make it the new centre.