Article

Siamese cat tyrosinase has enhanced proteasome degradation and increased cellular aggregation

2020-06-04

Abstract excerpt

Siamese cats are a notable example of a temperature-sensitive partial albinism phenotype. The signature color-pointing pattern is the result of an amino acid substitution – G302R – in the cysteine-rich domain of feline tyrosinase. The precise mechanism for the loss of tyrosinase enzyme activity due to this mutation is unknown. <h4>Objective</h4> We have used a cellular biology approach to begin unravel relationsh...

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Literature Corpus work: a2d2f0a0-94be-515a-b427-855e9b039b01
DOI: 10.1101/2020.06.03.132613

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