Article

Thrombospondin-4 (TSP4) gene-modified bone marrow stromal cells (BMSCs) promote the effect of therapeutic angiogenesis in critical limb ischemia (CLI) of diabetic rats

2019-10-09

Abstract excerpt

<title>Abstract</title> <p>Background: Critical limb ischemia (CLI) is the leading cause of lower limb amputation. Traditional treatments for CLI have limitations. Studies have shown that thrombospondin-4 (TSP4) can promote the growth of neovascularization. <h4>Results:</h4> In this study, we observed the angiogenesis efficiency of TSP4-overexpressing BMSC transplantation in CLI treatment. The recombinant FT106-t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a2d26551-e3d7-5094-b039-fcfaef06c20f
DOI: 10.21203/rs.2.15779/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Thrombospondin-4 (TSP4) gene-modified bone marrow stromal cells (BMSCs) promote the effect of therapeutic angiogenesis in critical limb ischemia (CLI) of diabetic ratsDOI 10.21203/rs.2.15779/v1Read

Thrombospondin-4 (TSP4) gene-modified bone marrow stromal cells (BMSCs) promote the effect of therapeutic angiogenesis in critical limb ischemia (CLI) of diabetic ratsSemantic proximity Read

Human Umbilical Cord-Derived Mesenchymal Stem Cells Relieve Hind Limb Ischemia by Promoting Angiogenesis in MiceSemantic proximity Read

Vascular regeneration and skeletal muscle repair induced by long-term exposure to SDF-1α derived from engineered mesenchymal stem cells after hindlimb ischemiaSemantic proximity Read

Preclinical Evaluation of Bone Marrow Mesenchymal Stem Cells Overexpressing MicroRNA-126 to Treat Critical Limb IschemiaSemantic proximity Read

Double VEGF/HGF Gene Therapy in Critical Limb Ischemia Complicated by Diabetes MellitusSemantic proximity Read

Human expression patterns: qualitative and quantitative analysis of thrombospondin‐1 under physiological and pathological conditionsSemantic proximity Read

Thrombospondin-1 is a plasmatic marker of peripheral arterial disease that modulates endothelial progenitor cell angiogenic properties.Semantic proximity Read

The molecular mechanism of thrombospondin family members in cardiovascular diseasesSemantic proximity Read

Analyses of the pericyte transcriptome in ischemic skeletal musclesSemantic proximity Read

The role of therapeutic MicroRNA in arteriogenesis process in limb ischemia: A systematic reviewSemantic proximity Read

Two-Stage Gene Therapy (VEGF, HGF and ANG1 Plasmids) as Adjunctive Therapy in the Treatment of Critical Lower Limb Ischemia in Diabetic Foot SyndromeSemantic proximity Read

Angiogenic cell therapy for critical limb ischemia: an update on concepts and trials.Semantic proximity Read