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Article

The role of FYCO1-dependent autophagy in lens fiber cell differentiation

28 Mar 2022

Abstract excerpt

FYCO1 (FYVE and coiled-coil domain containing 1) is an adaptor protein, expressed ubiquitously and required for microtubule-dependent, plus-end-directed transport of macroautophagic/autophagic vesicles. We have previously shown that loss-of-function mutations in FYCO1 cause cataracts with no other ocular and/or extra-ocular phenotype. Here, we show fyco1 homozygous knockout (fyco1−/−) mice recapitulate the...

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PMID: 35343376
DOI: 10.1080/15548627.2022.2025570

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