Article

Clinical evaluation of BCL-2/X<sub>L</sub> levels pre- and post- HER2-targeted therapy

2021-01-28

Abstract excerpt

<h4>ABSTRACT</h4> Our previous pre-clinical work defined BCL-2 induction as a critical component of the adaptive response to lapatinib-mediated inhibition of HER2. To determine whether a similar BCL-2 upregulation occurs in lapatinib-treated patients, we evaluated gene expression within tumor biopsies, collected before and after lapatinib or trastuzumab treatment, from the TRIO-B-07 clinical trial (NCT#00769470)....

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Literature Corpus work: a1af2ba2-6483-5a0c-8a14-cedeff8319c5
DOI: 10.1101/2021.01.26.21250250

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