Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MPA alters metabolic phenotype of endometrial cancer-associated fibroblasts from obese women via IRS2 signaling.

PloS one - 1 Jan 2022

Omar Intan Sofia, Abd Jamil Amira Hajirah, Mat Adenan Noor Azmi, Chung Ivy

Abstract excerpt

Obese women have a higher risk of developing endometrial cancer (EC) than lean women. Besides affecting EC progression, obesity also affects sensitivity of patients to treatment including medroxprogesterone acetate (MPA). Obese women have a lower response to MPA with an increased risk for tumor recurrence. While MPA inhibits the growth of normal fibroblasts, human endometrial cancer-associated fibroblasts (CAFs)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetates
Share to Cancer-Associated Fibroblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endometrial Neoplasms

Share to Insulin Receptor Substrate Proteins

Share to Mifepristone

Share to Neoplasm Recurrence, Local

Share to Progesterone

Share to Receptors, Progesterone

Source

Open in PubMed Open full text

Identifiers

PMID: 35816477
DOI: 10.1371/journal.pone.0270830
PMCID: PMC9273069

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MPA alters metabolic phenotype of endometrial cancer-associated fibroblasts from obese women via IRS2 signaling.PMID 35816477Read ↗

Raman spectroscopy differentiates obesity-associated lipid metabolic fingerprints in MPA- sensitive and resistant endometrial cancer-associated fibroblastsSemantic proximity Read ↗

Insulin-like Growth Factor 1 (IGF1) and Its Isoforms: Insights into the Mechanisms of Endometrial CancerSemantic proximity Read ↗

Molecular profiling of endometrial carcinoma precursor, primary and metastatic lesions suggests different targets for treatment in obese compared to non-obese patients.Semantic proximity Read ↗

Molecular Impact of Metabolic and Endocrine Disturbance on Endometrial Function in Polycystic Ovary SyndromeSemantic proximity Read ↗

Endometrial Hyperplasia Risk Is Increased by High-Fat Diet Via Estrogen-Driven Stromal Fibroblast Reprogramming Toward a Pro-Fibrotic StateSemantic proximity Read ↗

Lipid metabolism reprogramming in endometrial cancer: biological functions and therapeutic implicationsSemantic proximity Read ↗

Proteomic and bioinformatic analysis of human endometrium from polycystic ovarian syndrome with and without insulin resistanceSemantic proximity Read ↗

Lipid Reprogramming Induced by TFEB-ERRα Axis Enhanced Membrane Fluidity to Promote EC ProgressionSemantic proximity Read ↗

Transcriptome Profiles of Human Visceral Adipocytes in Obesity and Colorectal Cancer Unravel the Effects of Body Mass Index and Polyunsaturated Fatty Acids on Genes and Biological Processes Related to TumorigenesisSemantic proximity Read ↗

UTERINE FIBROIDS.Semantic proximity Read ↗

Does an increased body mass index affect endometrial gene expression patterns in infertile patients? A functional genomics analysis.Semantic proximity Read ↗

Endometrial cancer evolution: new molecular-biologic types and hormonal-metabolic shifts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.