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A Transcriptomics-Based Computational Drug Repurposing Pipeline Identifies Simvastatin And Primaquine As Therapeutics For Endometriosis

2025-05-30

Abstract excerpt

<h4>ABSTRACT</h4> Endometriosis has limited treatment options, prompting the search for novel therapeutics. We previously used a transcriptomics-based computational drug repositioning pipeline to analyze public bulk transcriptomic data of eutopic endometrium from cases and controls and identified several drug candidates. Fenoprofen, our top in silico candidate, was validated in a rat model of endometriosis-associ...

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Literature Corpus work
a1963400-018b-5b93-823a-ff81446201dc
DOI
10.1101/2025.05.28.656743
Open publication

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A Transcriptomics-Based Computational Drug Repurposing Pipeline Identifies Simvastatin And Primaquine As Therapeutics For EndometriosisDOI 10.1101/2025.05.28.656743
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