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Commensal or pathogen: computationally vectorizing microbial genomes for <i>de novo</i> risk assessment and virulence feature discovery in <i>Klebsiella pneumoniae</i>

2024-05-13

Abstract excerpt

Bacterial pathogenicity has traditionally focused on gene-level content with experimentally-confirmed functional properties. Hence, significant inferences are made based on similarity to known pathotypes and DNA-based genomic subtyping for risk. Herein, we achieved de novo prediction of human virulence in Klebsiella pneumoniae by expanding known virulence genes with spatially proximal gene discoveries linked by...

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Literature Corpus work
a179c516-2cdf-5559-8d23-99be1e8ed2a7
DOI
10.1101/2024.05.13.593956
Open publication

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