Article

FlowTransOP: Distributional Translation of Omics Signatures via Constrained Deep Flow Matching

2026-05-29

Abstract excerpt

Observations from pre-clinical models rarely generalize to human patients, leading to many failures in clinical trials. Most existing methods cannot handle domains with non-overlapping features and no paired samples. Here, we developed FlowTransOP to translate biological observations across such domains without requiring 1-to-1 feature mappings and paired data, while providing a guideline for model selection acros...

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Literature Corpus work: a0e52813-6811-59e9-aebf-265fc43e8a8a
DOI: 10.64898/2026.05.27.728305

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