Article

Direct Crystal Formation from Micronized Bone and Lactic Acid: The Writing on the Wall for Calcium-Containing Crystal Pathogenesis in Osteoarthritis?

2018-08-03

Abstract excerpt

<h4>Introduction</h4> Pathological calcium-containing crystals accumulating in the joints, synovial fluid, and soft tissues are noted in most elderly patients, yet arthritic crystal formation remains idiopathic. Interestingly, elevated lactic acid and bone erosion are frequently among the comorbidities and clinical features of patients with highest incidence of crystal arthropathies. This work shows that bone par...

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Literature Corpus work: a0dc0e47-b431-580b-adee-890b798f3c77
DOI: 10.1101/384669

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