Article

Perilipin-1 autoantibodies linked to idiopathic lipodystrophy in the setting of two distinct breaks in immune tolerance

2021-09-28

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Acquired lipodystrophy is often characterized as an idiopathic subtype of lipodystrophy. Despite suspicion of an immune-mediated pathology, biomarkers such as autoantibodies are generally lacking. <h4>Methods</h4> Here, we used an unbiased proteome-wide screening approach to identify autoantibodies to the adipocyte specific lipid droplet protein Perilipin-1 in a murine model o...

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Literature Corpus work: a0604058-0a67-51cc-a2b0-5023e3f6ae85
DOI: 10.1101/2021.09.24.21263657

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