Article

Studying of RNA-protein interactions between a mutant form of glycyl-tRNA synthetase associated with neurodegenerative diseases and IRES type I

2023-03-30

Abstract excerpt

Aminoacyl-tRNA synthetases (aaRS) are the main enzymes of protein biosynthesis. Human glycyl-tRNA synthetase, in addition to the main function of amino acid transfer to the corresponding tRNA molecules, is also involved in the initiation of IRES I translation. All members of the enterovirus genus have this type of IRES. It is also known that the presence of point mutations in aaRS leads to the occurrence of diseas...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9efd53a0-565f-5ba5-ba48-de3751be3b68
DOI: 10.1101/2023.03.29.534367

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Studying of RNA-protein interactions between a mutant form of glycyl-tRNA synthetase associated with neurodegenerative diseases and IRES type IDOI 10.1101/2023.03.29.534367Read

Associations between Neurological Diseases and Mutations in the Human Glycyl-tRNA Synthetase.Semantic proximity Read

Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase.Semantic proximity Read

Aminoacyl-tRNA synthetases in Charcot-Marie-Tooth disease: A gain or a loss?Semantic proximity Read

Searching for non-canonical functions of aminoacyl-tRNA synthases based on mutations carried by Charcot-Marie-Tooth patientsSemantic proximity Read

[aaRS--the etiological factor and the attractive target of many disorders].Semantic proximity Read

Aminoacyl-tRNA synthetases: Structure, function, and drug discovery.Semantic proximity Read

Crystallization and preliminary X-ray analysis of a native human tRNA synthetase whose allelic variants are associated with Charcot-Marie-Tooth disease.Semantic proximity Read

The role of aminoacyl-tRNA synthetases in genetic diseases.Semantic proximity Read

A disease-causing Isoleucyl-tRNA synthetase variant leads to altered protein complex formation and cellular stress responseSemantic proximity Read

A disease-causing isoleucyl-tRNA synthetase variant leads to altered protein complex formation and cellular stress response.Semantic proximity Read

Glycyl-tRNA sequestration is a unifying mechanism underlying <i>GARS1</i> -associated peripheral neuropathySemantic proximity Read

Large Conformational Changes of Insertion 3 in Human Glycyl-tRNA Synthetase (hGlyRS) during Catalysis.Semantic proximity Read