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Unsupervised generative AI discovers pan-leukocyte dysregulated pathways in single-cell lupus data

2024-03-06

Abstract excerpt

Comparisons of single-cell RNA-sequencing (scRNA-seq) data from healthy and diseased tissues are widely used to identify cell-type-specific dysregulated genes, pathways, and processes. Accordingly, many sophisticated methods have been developed for this purpose. However, such tools generally require considerable user expertise for optimal performance. Here, we show that unsupervised application of a linearly-decod...

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Identifiers and source

Literature Corpus work
9ece7b04-fcb3-5819-a288-e4ad9c84b413
DOI
10.1101/2024.03.02.583143
Open publication

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Unsupervised generative AI discovers pan-leukocyte dysregulated pathways in single-cell lupus dataDOI 10.1101/2024.03.02.583143
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