Article

Deep Clinical Phenotyping of Planar Perugini Grade 1 on Bone Scintigraphy: An Imaging-Phenotype Association Study

2026-07-01

Abstract excerpt

<h4>Aims</h4> Planar Perugini grade 1 is equivocal for transthyretin amyloid cardiomyopathy (ATTR-CM), has no dedicated management pathway and is heterogeneous, spanning low-burden amyloid and non-amyloid blood-pool activity. Rather than treating it as a step toward amyloid confirmation, we characterized the clinical phenotype grade 1 marks and tested whether that phenotype accounts for its prognosis. <h4>Methods...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9db59b94-e451-5dff-a611-aacc655b4544
DOI: 10.64898/2026.06.29.26356893

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deep Clinical Phenotyping of Planar Perugini Grade 1 on Bone Scintigraphy: An Imaging-Phenotype Association StudyDOI 10.64898/2026.06.29.26356893Read

Detecting early cardiomyopathy in transthyretin variant carriers: reappraising the diagnostic value of Perugini Grade 1 radiotracer uptake on bone scintigraphySemantic proximity Read

Gated SPECT/CT uptake patterns in ATTR-CA: Association with myocardial burden, function and prognosisSemantic proximity Read

Soft Tissue-to-Bone Ratio on Routine Bone Scintigraphy as an Opportunistic Imaging Biomarker of Cardiovascular-Kidney-Metabolic BurdenSemantic proximity Read

Multi-Imaging Characterization of Cardiac Phenotype in Different Types of Amyloidosis.Semantic proximity Read

Cardiac amyloidosis: the great pretender.Semantic proximity Read

Clinical and Phenotypic Characterization of Hereditary Transthyretin Amyloidosis (ATTRv) in Peruvian Population: First Case Series IMPAC-FE StudySemantic proximity Read

Diversity of heart failure phenotypes in transthyretin amyloid cardiomyopathy. More than just heart failure with preserved ejection fraction.Semantic proximity Read

Clinical, Genetic and Phenotypic Characterization of Hereditary Transthyretin Amyloidosis (ATTRv) in Peruvian Population: Real-World Data from a Case Series — IMPAC-FE StudySemantic proximity Read

Transthyretin cardiac amyloid: Broad heart failure phenotypic spectrum and implications for diagnosis.Semantic proximity Read

Apolipoprotein 1 amyloidosis cardiomyopathy and the grey zone of non-invasive diagnostic algorithms: Red flags to reach the diagnosis.Semantic proximity Read

Small Hearts, Big Clues: Amyloidosis in WomenSemantic proximity Read

Clinical comparison of V122I genotypic variant of transthyretin amyloid cardiomyopathy with wild-type and other hereditary variants: a systematic review.Semantic proximity Read