Article

Soft Tissue-to-Bone Ratio on Routine Bone Scintigraphy as an Opportunistic Imaging Biomarker of Cardiovascular-Kidney-Metabolic Burden

2026-06-09

Abstract excerpt

<h4>Background</h4> Cardiovascular-kidney-metabolic (CKM) syndrome is a leading driver of cardiovascular morbidity and mortality. Whole-body molecular imaging is well-positioned to phenotype such syndromes, yet no imaging biomarker quantifies cumulative CKM burden. Bone scintigraphy with 99m Tc-labeled bisphosphonates is widely performed and expanding with transthyretin amyloidosis assessment, under which Perugi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 88687120-bd29-50ea-aafe-a43077b50bb2
DOI: 10.64898/2026.06.08.26355179

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Soft Tissue-to-Bone Ratio on Routine Bone Scintigraphy as an Opportunistic Imaging Biomarker of Cardiovascular-Kidney-Metabolic BurdenDOI 10.64898/2026.06.08.26355179Read

Deep Clinical Phenotyping of Planar Perugini Grade 1 on Bone Scintigraphy: An Imaging-Phenotype Association StudySemantic proximity Read

The prevalence of TTR cardiac amyloidosis among patients undergoing bone scintigraphy.Semantic proximity Read

Multi-Imaging Characterization of Cardiac Phenotype in Different Types of Amyloidosis.Semantic proximity Read

Low Sensitivity of Bone Scintigraphy in Detecting Phe64Leu Mutation-Related Transthyretin Cardiac Amyloidosis.Semantic proximity Read

Detecting early cardiomyopathy in transthyretin variant carriers: reappraising the diagnostic value of Perugini Grade 1 radiotracer uptake on bone scintigraphySemantic proximity Read

Incremental Prognostic Value of Pericardial Adipose Tissue Radiomic Phenotype Based on Cardiac MRI in Patients With End-Stage Renal Disease.Semantic proximity Read

Multivascular Imaging-Derived Atherosclerotic Burden and Cardiorenal Outcomes in Non-Dialysis Chronic Kidney DiseaseSemantic proximity Read

Gated SPECT/CT uptake patterns in ATTR-CA: Association with myocardial burden, function and prognosisSemantic proximity Read

Molecular imaging along the heart-kidney axisSemantic proximity Read

Imaging-based characterization of cardiometabolic phenotypes focusing on whole-body MRI--an approach to disease prevention and personalized treatment.Semantic proximity Read

Predictive value of β2 microglobulin for Cardiac Valve Calcification in Non-Dialysis Patients with Chronic Kidney Disease Stages 3-5Semantic proximity Read

Echocardiographic phenotype in severe aortic stenosis with and without transthyretin cardiac amyloidosis: the AMY-TAVI study.Semantic proximity Read