Article

The use of electron microscopy in the diagnosis of focal segmental glomerulosclerosis: are current pathological techniques missing important abnormalities in the glomerular basement membrane?

2019-11-07

Abstract excerpt

<h4>Background: </h4> There is an increasing appreciation that variants of the COL4A genes may be associated with the development of focal segmental glomerulosclerosis (FSGS). On electron microscopy, such variants may produce characteristic changes within the glomerular basement membrane (GBM). These changes may be missed if glomerular lesions histologically diagnosed as FSGS on light microscopy are not subjected...

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Literature Corpus work: 9d17ae46-bc55-5b4a-b749-99186b9ca372
DOI: 10.12688/f1000research.19997.2

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