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Article

Absence of mutations in the gene encoding thyroid transcription factor-1 (TTF-1) in patients with thyroid dysgenesis.

Thyroid : official journal of the American Thyroid Association - 1 Jun 1997

Perna M G, Civitareale D, De Filippis V, Sacco M, Cisternino C, Tassi V

Abstract excerpt

Thyroid transription factor-1 (TTF-1) is a homeodomain-containing nuclear transcription factor, important in regulation of the thyroid-specific genes thyroglobulin (Tg), thyroperoxidase (TPO), and thyrotropin receptor (TSHR). TTF-1 is an early biochemical marker of thyroid differentiation, essential for thyroid development and maintenance of the thyroid differentiated state. It is possible that mutations in titf1...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9226206
DOI: 10.1089/thy.1997.7.377

Genes

TPO
TSHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Absence of mutations in the gene encoding thyroid transcription factor-1 (TTF-1) in patients with thyroid dysgenesis.PMID 9226206Read ↗

Sequence analysis of thyroid transcription factor-1 gene reveals absence of mutations in patients with thyroid dysgenesis but presence of polymorphisms in the 5' flanking region and intron.Semantic proximity Read ↗

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Partial deficiency of Thyroid transcription factor 1 produces predominantly neurological defects in humans and miceSemantic proximity Read ↗

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Partial deficiency of thyroid transcription factor 1 produces predominantly neurological defects in humans and mice.Semantic proximity Read ↗

Characterization of mutations in the FOXE1 gene in a cohort of unrelated Malaysian patients with congenital hypothyroidism and thyroid dysgenesis.Semantic proximity Read ↗

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