Article

RIPK3-RNASE1 axis as a potential therapeutic and clinical monitoring target in VEXAS syndrome

2026-02-06

Abstract excerpt

Vacuole, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome (VS) is a severe autoinflammatory disease driven by somatic mutations in ubiquitin-like modifier activating enzyme 1 ( UBA1 ), for which disease activity biomarkers and therapeutic targets are needed. We conducted longitudinal deep phenotyping of patients with VS and found that ribonuclease 1 ( RNASE1 ) expression is most strongly correlate...

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Literature Corpus work: 9b64702d-15d2-5bf4-acb9-0cbfb9ec2931
DOI: 10.64898/2026.02.04.703672

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