Article

Characterization of non-monotonic relationships between tumor mutational burden and clinical outcomes

2024-01-20

Abstract excerpt

<h4>ABSTRACT</h4> Potential clinical biomarkers are often assessed with Cox regressions or their ability to differentiate two groups of patients based on a single cutoff. However, both of these approaches assume a monotonic relationship between the potential biomarker and survival. Tumor mutational burden (TMB) is currently being studied as a predictive biomarker for immunotherapy, and a single cutoff is often us...

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Literature Corpus work: 9b63d4f0-40ab-5d31-b730-f5c863350cd1
DOI: 10.1101/2024.01.16.575937

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