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Pluripotent stem cell–derived extracellular vesicles for systemic immune modulation in diabetes therapy

2025-06-10

Abstract excerpt

<title>Abstract</title> <p>Embryos can achieve immune tolerance, yet the underlying mechanisms remain incompletely understood. Here, we demonstrate that pluripotent stem cells (PSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), secrete extracellular vesicles (EVs) that markedly outperform mesenchymal stem cell (MSC)–derived EVs in suppressing pro-inflammatory cytokine secreti...

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Literature Corpus work
9b19ac31-7e76-5c8c-8e93-b965434a7458
DOI
10.21203/rs.3.rs-6415252/v1
Open publication

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