Article

Lack of evidence of ACE2 expression and replicative infection by SARS-CoV-2 in human endothelial cells

2020-12-02

Abstract excerpt

A striking feature of severe COVID-19 is thrombosis in large as well as small vessels of multiple organs. This has led to the assumption that SARS-CoV-2 virus directly infects and damages the vascular endothelium. However, endothelial expression of ACE2, the cellular receptor for SARS-CoV-2, has not been convincingly demonstrated. Interrogating human bulk and single-cell transcriptomic data, we found ACE2 express...

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Literature Corpus work: 97ddcf8d-873d-51bd-bb1d-4d9719fa1285
DOI: 10.1101/2020.12.02.391664

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