Article

Parameterization of the PA endonuclease bimetallic center reveals the dynamics of clinically relevant mutations

2026-06-16

Abstract excerpt

Influenza A virus continues to impose a major global health and economic burden through seasonal epidemics and occasional pandemics, highlighting the critical need for continued antiviral development. As the latest addition to anti-influenza therapy, baloxavir marboxil (BXM) targets the highly conserved PA N-terminal endonuclease domain (PAN), blocking the cap-snatching process essential for viral transcription in...

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Literature Corpus work: 97cfdfc1-09d8-56e5-bc7f-29344e807593
DOI: 10.64898/2026.06.12.731895

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