Article

Lipoxygenases and CFTR Inhibitory Factors Might Share the Same Role in Host-Microbe Interactions

2026-02-26

Abstract excerpt

Cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel in humans and other vertebrates, whose mutation leads to cystic fibrosis. CFTR inhibitory factor — Cif — is a recently discovered bacterial epoxide hydrolase that downregulates CFTR protein upon the bacterial infection. However, its cleaving activity towards fatty acid epoxides — epoxygenase-derived oxylipins — has been recently chara...

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Literature Corpus work: 954901dc-fe55-54a8-b2a0-02b557920a99
DOI: 10.20944/preprints202602.1829.v1

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