Article
Translating genome-wide association findings into new therapeutics for psychiatry.
Nature neuroscience - 26 Oct 2016
Breen Gerome, Li Qingqin, Roth Bryan L, O'Donnell Patricio, Didriksen Michael, Dolmetsch Ricardo, O'Reilly Paul F, Gaspar Héléna A, Manji Husseini, Huebel Christopher, Kelsoe John R, Malhotra Dheeraj, Bertolino Alessandro, Posthuma Danielle, Sklar Pamela, Kapur Shitij, Sullivan Patrick F, Collier David A, Edenberg Howard J
Abstract excerpt
Genome-wide association studies (GWAS) in psychiatry, once they reach sufficient sample size and power, have been enormously successful. The Psychiatric Genomics Consortium (PGC) aims for mega-analyses with sample sizes that will grow to >1 million individuals in the next 5 years. This should lead to hundreds of new findings for common genetic variants across nine psychiatric disorders studied by the PGC. The new...
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