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Inducible colistin resistance via a disrupted plasmid-borne <i>mcr-1</i> gene in a 2008 Vietnamese <i>Shigella sonnei</i> isolate

2016-02-18

Abstract excerpt

The mcr-1 gene, which confers resistance against the last-resort antimicrobial colistin, was recently discovered in Enterobacteriaceae circulating in China. Through genome sequencing we identified a plasmid-associated inactive form of mcr-1 in a 2008 Vietnamese isolate of Shigella sonnei . The plasmid was conjugated into E. coli and mcr-1 was activated upon exposure to colistin, suggesting the gene has been c...

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Literature Corpus work: 94316cd5-8772-5eca-a74f-4833cb9d9907
DOI: 10.1101/039925

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