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Single-Cell Transcriptome Identifies the Renal Cell Type Tropism of Human BK Polyomavirus

10 Jan 2023

Abstract excerpt

BK polyomavirus (BKPyV) infection is the main factor affecting the prognosis of kidney transplant recipients, as no antiviral agent is yet available. A better understanding of the renal-cell-type tropism of BKPyV can serve to develop new treatment strategies. In this study, the single-cell transcriptomic analysis demonstrated that the ranking of BKPyV tropism for the kidney was proximal tubule cells (PT),...

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PMID: 36674845
DOI: 10.3390/ijms24021330

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