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Article

Identification of Novel Genetic Variants in CVID Patients With Autoimmunity, Autoinflammation, or Malignancy.

Frontiers in immunology - 1 Jan 2019

Christiansen Mette, Offersen Rasmus, Jensen Jens Magnus Bernth, Petersen Mikkel Steen, Larsen Carsten S, Mogensen Trine H

Abstract excerpt

Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by recurrent bacterial infections and defined by reduced levels of IgG, IgA, and/or IgM, insufficient response to polysaccharide vaccination, and an abnormal B-cell immunophenotype with a significantly reduced fraction of isotype-switched memory B cells. In addition to this infectious phenotype, at least one third of the patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32047491
DOI: 10.3389/fimmu.2019.03022
PMCID: PMC6996488

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