Article

Defining the Transcriptional Landscape during Cytomegalovirus Latency with Single-Cell RNA Sequencing

2017-10-25

Abstract excerpt

Primary infection with human cytomegalovirus (HCMV) results in a lifelong infection due to its ability to establish latent infection, one characterized viral reservoir being hematopoietic cells. Although reactivation from latency causes serious disease in immunocompromised individuals, our molecular understanding of latency is limited. Here, we delineate viral gene expression during natural HCMV persistent infecti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9152b77e-1926-5246-b372-5360a078a70e
DOI: 10.1101/208603

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Defining the Transcriptional Landscape during Cytomegalovirus Latency with Single-Cell RNA SequencingDOI 10.1101/208603Read

Defining the Transcriptional Landscape during Cytomegalovirus Latency with Single-Cell RNA SequencingSemantic proximity Read

The Transcriptome of Latent Human CytomegalovirusSemantic proximity Read

Transcriptome-wide characterization of human cytomegalovirus in natural infection and experimental latencySemantic proximity Read

Temporal Dynamics of HCMV Gene Expression in Lytic and Latent InfectionsSemantic proximity Read

Temporal dynamics of HCMV gene expression in lytic and latent infectionsSemantic proximity Read

Multi-omics reveals principles of gene regulation and pervasive non-productive transcription in the human cytomegalovirus genomeSemantic proximity Read

Molecular characterization of human cytomegalovirus infection with single-cell transcriptomicsSemantic proximity Read

Single-Cell Analysis of Quiescent HIV Infection Reveals Host Transcriptional Profiles that Regulate Proviral LatencySemantic proximity Read

Human Cytomegalovirus Latent Infection and Associated Viral Gene ExpressionSemantic proximity Read

Dual Analysis of the Murine Cytomegalovirus and Host Cell Transcriptomes Reveal New Aspects of the Virus-Host Cell InterfaceSemantic proximity Read

Human cytomegalovirus IE2 drives transcription initiation from a select subset of late infection viral promoters by host RNA polymerase IISemantic proximity Read

Cytomegalovirus late transcription factor target sequence diversity orchestrates viral early to late transcriptionSemantic proximity Read