Dopaminergic drugs modulate fear extinction related processes in humans, but effects are mild

Abstract excerpt

The ability to extinguish learned fear responses is crucial for adaptive behavior. The mesolimbic dopaminergic system originating in the ventral tegmental area has been proposed to contribute to fear extinction learning because of its critical role in reward learning. The unexpected omission of aversive unconditioned stimuli (US) is considered as rewarding (outcome better than expected) and to drive extinction lea...

Topics

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• Arousal
• Association Learning
• Conditioning, Classical
• Fear
• Mental Recall
• Monoamine Oxidase
• Receptors, Dopamine D4
• Serotonin

Identifiers and source

Literature Corpus work

912b91e7-da55-5d74-9f66-59aafc537763

DOI

10.1101/2025.04.11.648372