Development of a Prognostic Model for HR-positive HER2-negative and Node-negative Breast Cancer: Integrating Clinical and Transcriptional Biomarkers

Abstract excerpt

<title>Abstract</title> <p>Purpose In this study, a prognostic model was constructed for HR-positive HER2-negative (HR+/HER2–) and node-negative breast cancer by integrating clinical and transcriptional biomarkers, with a particular focus on exploring both main effects and gene-gene (G × G) interactions. Methods Univariate and multivariate Cox regression were used to analyze three independent trans-ethnic cohor...

Topics

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• Biomarkers, Tumor
• Cell Line, Tumor
• Gene Expression Profiling
• Gene Expression Regulation, Neoplastic
• Gene Regulatory Networks
• Transcription Factors
• Transcriptome
• Triple Negative Breast Neoplasms

Identifiers and source

Literature Corpus work

903f2416-60d8-5c84-9c4a-86b4a6c41c5f

DOI

10.21203/rs.3.rs-4394836/v1