Article

Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich’s ataxia patient cells

2020-03-28

Abstract excerpt

The molecular mechanisms of reduced frataxin ( FXN ) expression in Friedreich’s ataxia (FRDA) are linked to epigenetic modification of the FXN locus caused by the disease-associated GAA expansion. Here, we identify that SUV4-20 histone methyltransferases, specifically SUV4-20 H1, play an important role in the regulation of FXN expression and represent a novel therapeutic target. Using a human FXN -GAA-Lucifera...

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Literature Corpus work: 8fef82d7-77ab-5cee-b67d-095bf4f4db9b
DOI: 10.1101/2020.03.26.010439

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