Article

Reversible biological motion with unidirectional catalysis through inversion of ATPase orientation

2026-02-25

Abstract excerpt

Biological and engineered machines generally achieve reversibility through regulated switches in the directionality of fixed-orientation motors. Bacterial Tad pilus nanomachines extend and retract pili using a single motor with a unidirectional catalytic mechanism, a capability with no precedent. Using AlphaFold3 modeling, comparative structural analyses, and pilus activity assays, we find that the Tad motor ATPas...

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Literature Corpus work: 8d8e3a0a-38fc-5872-871e-fc0cbe5a5f8e
DOI: 10.64898/2026.02.24.707734

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