Article

The prevalence of protein misfolding as a mechanism for hereditary deafness

2026-03-11

Abstract excerpt

Hearing loss is the most common sensory deficit impacting ∼5% of the world’s population. The Deafness Variation Database (DVD) is a public resource of deafness variants, containing over 380,000 missense variants across 224 genes, with 303,577 classified as a variant of uncertain significance (VUS). To address the challenge of evaluating each deafness associated VUS, we evaluate a family of probabilistic frameworks...

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Literature Corpus work: 8c897ba3-ee68-5073-b3b3-cc0d5eeb0f0c
DOI: 10.64898/2026.03.09.710547

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