Article

Folliculin Haploinsufficiency Causes Cellular Dysfunction of Pleural Mesothelial Cells

2021-01-18

Abstract excerpt

Birt–Hogg–Dubé syndrome ( BHDS ), an autosomal dominant inheritance disease caused by folliculin ( FLCN ) mutations, is associated with lung cysts and spontaneous pneumothorax. The possibility of FLCN haploinsufficiency in pleural mesothelial cells (PMCs) contributing to development of pneumothorax has not yet been clarified. Electron microscopy revealed exposed intercellular boundaries between PMCs on visceral pl...

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Literature Corpus work: 8c665a7b-3f9f-5021-b006-a5a468ac213a
DOI: 10.21203/rs.3.rs-144122/v1

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