Article

A novel Variant in GAS2 Is Associated with Non-Syndromic Autosomal Dominant Hearing Impairment in a Chinese Family

2024-02-14

Abstract excerpt

Mutation in the GAS2 gene, encoding growth arrest-specific protein 2 (GAS2), causes the disorganization and destabilization of microtubule bundles in supporting cells of the cochlear duct, leading to hearing loss in vivo . The expression and function of GAS2 in cochlear duct is confirmed. However, the molecular mechanism of GAS2 mutant resulting in hearing loss is still unknown. Whole exome sequencing (WES) was em...

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Literature Corpus work: 8c1b22d1-7e8e-58fe-bdef-cfc315e8c1a1
DOI: 10.21203/rs.3.rs-3936432/v1

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