Article

Orbitofrontal-striatal structural alterations linked to negative symptoms at different stages of the schizophrenia spectrum

2020-04-10

Abstract excerpt

Among the most debilitating manifestations of schizophrenia are negative symptoms such as anhedonia and apathy. Imaging studies have linked these symptoms to morphometric abnormalities in two brain regions implicated in reward and motivation: the orbitofrontal cortex (OFC) and ventral striatum. Negative symptoms generally are associated with reduced OFC thickness, while apathy specifically maps to reduced striatal...

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Literature Corpus work: 8b1a8694-5f5a-5ccb-a8b4-f9a4d0363ccb
DOI: 10.1101/2020.04.07.20057166

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