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CircRNA hypomethylation in the human amygdala implicates <i>FKBP5</i> in alcohol use disorder

2025-05-04

Abstract excerpt

Genome- and phenome-wide association studies implicate the RNA demethylase FTO in alcohol use disorder (AUD), yet the RNA methylation landscape in AUD remains poorly characterized. Analyzing postmortem human basolateral amygdala (BLA) tissue, a key brain region in AUD-related behaviors, we found extensive m 6 A hypomethylation uniquely affecting circular RNAs (circRNAs). Notably, FKBP5 -hosted circRNAs (circFKB...

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Identifiers and source

Literature Corpus work
8a4f737e-59ed-5149-bfe3-47d806335e7a
DOI
10.1101/2025.05.04.652083
Open publication

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CircRNA hypomethylation in the human amygdala implicates <i>FKBP5</i> in alcohol use disorderDOI 10.1101/2025.05.04.652083
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