The Zika Virus Persistently Infects Retinal Pigment Epithelial Cells, Eliciting Limited Cytopathic Effects and Loss of Epithelial Characteristics Consistent with Epithelial-Mesenchymal Transition

Abstract excerpt

The Zika virus (ZIKV), a pathogenic member of the orthoflavivirus family, is raising serious health concerns worldwide. Like Dengue (DENV) and Chikungunya (CHIKV) viruses, it is one of the arboviruses that poses an emerging threat to areas where its main vectors, Aedes mosquitoes, proliferate, well beyond tropical and subtropical regions. Although often asymptomatic or mild, ZIKV infection has been responsible fo...

Topics

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• COVID-19 Impact on Reproduction
• Insect symbiosis and bacterial influences
• Malaria Research and Control
• Mosquito-borne diseases and control
• Retinal and Optic Conditions
• Retinal Imaging and Analysis
• Viral Infections and Vectors
• Virology and Viral Diseases

Identifiers and source

Literature Corpus work

8998f069-955e-51d2-9b2a-36f031484322

DOI

10.1101/2025.07.19.665681