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T2T-YAO: a Telomere-to-telomere Assembled Diploid Reference Genome for Han Chinese

2023-07-19

Abstract excerpt

Since its initial release in 2001, the human reference genome has been continuously improved in both continuity and accuracy, and the recently-released telomere-to-telomere version—T2T-CHM13—reaches its top quality after 20 years of effort. However, T2T-CHM13 does not represent an authentic diploid human genome, but rather one derived from a simplified, nearly homozygous genome of a hydatidiform mole cell line. To...

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Literature Corpus work
89620aaa-11f2-5089-83f3-0d0c1bd81a9e
DOI
10.1101/2023.07.17.549286
Open publication

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