Article

Physicochemical characteristics of abiraterone acetate used for the treatment of prostate cancer

2016-03-11

Abstract excerpt

Prostate cancer is the most common cancer among men and often has no early symptoms. The major treatment options that include surgical or medical castration cause ablation of the production of testosterone, dihydrotestosterone and related androgens by the testes. These procedures do not affect adrenal, prostate and other tissues androgen production, therefore they are combined with androgen receptor antagonists to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8953f72f-f01c-56ac-91a4-d292af062388
DOI: 10.7287/peerj.preprints.1850v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Physicochemical characteristics of abiraterone acetate used for the treatment of prostate cancerDOI 10.7287/peerj.preprints.1850v1Read

Genomic Investigation for Potential Therapeutic Use of Abiraterone in the Amazonian Indigenous PopulationSemantic proximity Read

In Silico Evaluation of the Binding Energies of Androgen Receptor Agonists in Wild-Type and Mutational Models.Semantic proximity Read

Prostate Cancer and Tea: CYP17A1 Inhibition by Phytochemicals from Tea Plant Camellia sinensis L. and Implications for Anti-androgenic EffectSemantic proximity Read

Modeling androgen receptor flexibility: a binding mode hypothesis of CYP17 inhibitors/antiandrogens for prostate cancer therapy.Semantic proximity Read

Antiandrogenic activity of anthranilic acid ester derivatives as novel lead structures to inhibit prostate cancer cell proliferation.Semantic proximity Read

<i>HSD3B1</i> genotype among metastatic castration-resistant prostate cancer patients: pharmacodynamics and clinical outcomes after treatment with abiraterone plus prednisoneSemantic proximity Read

[Mechanisms of resistance to CYP17A1 inhibitors in castrate resistant prostate cancer].Semantic proximity Read

Effect of food and polymorphisms in SLCO2B1, CYP3A4 and UGT1A4 on pharmacokinetics of abiraterone and its metabolites in Chinese volunteers.Semantic proximity Read

A Computational Approach to Evaluate the Androgenic Affinity of Iprodione, Procymidone, Vinclozolin and Their MetabolitesSemantic proximity Read

CYP17A1 polymorphisms and clinical outcome of castration-resistant prostate cancer patients treated with abiraterone.Semantic proximity Read

Abiraterone shows alternate activity in models of endocrine resistant and sensitive disease.Semantic proximity Read

Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model.Semantic proximity Read