Article

A stimulation-orthogonal neural biomarker of therapeutic response in deep brain stimulation

2026-07-02

Abstract excerpt

<title>Abstract</title> <p>Closed-loop neuromodulation requires a feedback signal that reports therapeutic state, yet such signals are typically read from the same circuits that stimulation is perturbing. A neural feature that changes during stimulation may therefore simply reflect engagement of the circuit rather than clinical improvement. This entanglement problem is common to any stimulation paradigm in which...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 89105652-4062-58bd-beb5-842dc3f4fdee
DOI: 10.21203/rs.3.rs-10206188/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A stimulation-orthogonal neural biomarker of therapeutic response in deep brain stimulationDOI 10.21203/rs.3.rs-10206188/v1Read

Subthalamic nucleus encoding steers adaptive therapies for gait in Parkinson’s diseaseSemantic proximity Read

Multitarget brain implants enable generalized decoding of Parkinson’s disease symptoms from chronic home recordingsSemantic proximity Read

A Preoperative Electroencephalography Signature for Predicting Treatment Response to Deep Brain Stimulation in Obsessive-Compulsive DisorderSemantic proximity Read

Decoding Motor Excitability in TMS using EEG-Features: An Exploratory Machine Learning ApproachSemantic proximity Read

Quantifying Dysregulation of fMRI-Derived Control Circuits for Computational PsychiatrySemantic proximity Read

Chronic wireless streaming of invasive neural recordings at home for circuit discovery and adaptive stimulationSemantic proximity Read

Spatially specific, closed-loop infrared thalamocortical deep brain stimulationSemantic proximity Read

A Scalable Framework for Closed-Loop Neuromodulation with Deep LearningSemantic proximity Read

Invasive neurophysiology and whole brain connectomics for neural decoding in patients with brain implantsSemantic proximity Read

Rapid Motor Fluctuations Reveal Short-Timescale Neurophysiological Biomarkers of Parkinson’s DiseaseSemantic proximity Read

Adaptive Neural Conditioning Using Latent Space Embeddings and Optical DataSemantic proximity Read

At-Home Movement State Classification Using Totally Implantable Bidirectional Cortical-Basal Ganglia Neural InterfaceSemantic proximity Read