Article

Multiple roles for TFG ring complexes in neuronal cargo trafficking

2024-11-05

Abstract excerpt

Pathological variants in Trk-fused gene (TFG) have been implicated in a variety of neurodegenerative conditions. In particular, mutations within its amino-terminal PB1 domain have been suggested to cause hereditary spastic paraplegia (HSP), resulting in progressive lower limb spasticity and weakness. The structural basis for this effect is unknown. Here, we combine X-ray crystallography and cryo-electron microscop...

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Literature Corpus work: 88af0ac8-aeeb-50b6-abc6-78d1259ca6eb
DOI: 10.1101/2024.11.05.621662

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