Article

Improved pathogen identification in sepsis or septic shock by clinical metagenomic sequencing

2025-04-06

Abstract excerpt

<h4>Summary</h4> <h4>Objectives.</h4> Despite limited sensitivity and specificity, blood cultures (BCs) still represent the gold standard of diagnostic care in septic patients. We aimed to overcome current diagnostic limitations by unbiased next-generation sequencing (NGS) of circulating microbial cell-free DNA (mcfDNA) in plasma samples. <h4>Methods.</h4> We performed a prospective, observational, non-interventio...

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Literature Corpus work: 8766e53f-a6f9-55da-b589-249004c42ef1
DOI: 10.1101/2025.04.04.25324949

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