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Improved pathogen identification in sepsis or septic shock by clinical metagenomic sequencing

6 Aug 2025

Abstract excerpt

OBJECTIVES: Despite limited sensitivity and specificity, blood cultures (BCs) still represent the gold standard of diagnostic care in septic patients. We aimed to overcome current diagnostic limitations by unbiased next-generation sequencing (NGS) of circulating microbial cell-free DNA (mcfDNA) in plasma samples. METHODS: We performed a prospective, observational, non-interventional, multicenter study (Next...

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PMID: 40774415
DOI: 10.1016/j.jinf.2025.106565

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