Back to search

Article

AI-Assisted Prompt Engineering Identifies KRT19 as a Genetically Validated Therapeutic Target

2025-09-28

Abstract excerpt

Artificial intelligence–assisted prompting offers a transformative strategy for rapidly identifying and contextualizing biological targets. Using Swalife PromptStudio, we present a case study of Keratin 19 (KRT19) demonstrates strong genetic evidence linking it to disease risk, particularly in fibrotic disorders and cancer. Genome-wide association studies (GWAS) reveal three significant hits at the KRT19 locus, wi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
8728268d-d6f2-5cde-87e3-2307cb77fec9
DOI
10.20944/preprints202509.2329.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
AI-Assisted Prompt Engineering Identifies KRT19 as a Genetically Validated Therapeutic TargetDOI 10.20944/preprints202509.2329.v1
Identification and Validation of YWHAZ Using AI Generated PromptsSemantic proximity
AI-Driven Validation of PKP3 as a Multifaceted Oncogenic HubSemantic proximity
Validation of KRT17 as a Multi-Dimensional Oncogenic Driver for Cancer Using AISemantic proximity
A Multi-Omics and Network Biology Case Study of CLIC1 Using AI Generated PromptsSemantic proximity
Prompt-Driven Target Identification: A Multi-Omics and Network Biology Case Study of PARP1 Using Swalife PromptStudioSemantic proximity
From GWAS Signals to Molecular Mechanisms: Explainable AI for Causal Gene Prioritization and Biomolecular Target Interpretation.Semantic proximity
Guided multi-agent AI invents highly accurate, uncertainty-aware transcriptomic aging clocksSemantic proximity
Designing AI-programmable therapeutics with the EDEN family of foundation modelsSemantic proximity
PersonaAI: An Interactive Agentic-AI Framework for Autonomous Hypothesis Generation and Validation in AgingSemantic proximity
CRISPR-GPT for Agentic Automation of Gene Editing ExperimentsSemantic proximity
Transitioning from Wet Lab to Artificial Intelligence: A Systematic Review of AI predictors in CRISPRSemantic proximity
LUMI-lab: a Foundation Model-Driven Autonomous Platform Enabling Discovery of New Ionizable Lipid Designs for mRNA DeliverySemantic proximity
Select a neighboring publication to make it the new centre.