Article

Heterozygous OTULIN-variant related fasciitis and skin necrosis treated by TNF inhibition.

2023-11-14

Abstract excerpt

<title>Abstract</title> <p>Here we describe an adult female with severe fasciitis and skin necrosis who carried a private, predicted deleterious missense mutation in <italic>OTULIN</italic> in heterozygozity. OTULIN is a cellular regulator of deubiquitination that has been shown to play a key role in intrinsic immunity against staphylococcal α-toxin. The patient was treated with broad spectrum antibiotics and mul...

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Identifiers and source

Literature Corpus work: 8650e262-ea1f-5f5a-a2c7-fb0b3bd527e3
DOI: 10.21203/rs.3.rs-3575283/v1

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