Article

Clinical utility of HRR gene methylation for predicting PARPi sensitivity in HGSOC patients

2025-10-31

Abstract excerpt

<h4>Objective: </h4> To develop a methylation-based predictive model for PARP inhibitor (PARPi) efficacy in advanced high-grade serous ovarian cancer (HGSOC) patients. <h4>Design: </h4> Retrospective analysis of tumor tissues from 96 advanced HGSOC patients receiving PARPi maintenance therapy (78 sensitive, 18 insensitive). <h4>Setting: </h4> A tertiary gynecologic oncology center at Women’s Hospital, Zhejiang U...

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Literature Corpus work: 86475e4a-8854-5c59-979d-02310970408c
DOI: 10.22541/au.176189052.21086158/v1

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