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Engineered phage endolysin eliminates <i>Gardnerella</i> in bacterial vaginosis without damaging the healthy vaginal microbiome

2020-10-27

Abstract excerpt

<h4>Background</h4> Bacterial vaginosis is characterized by an imbalance of the vaginal microbiome in which the normally predominant lactobacilli are replaced by other bacterial species. Initiated by strains of the bacterium Gardnerella , a characteristic biofilm forms on the vaginal epithelium, explaining the typical presence of clue cells. This biofilm contributes to the resilience of the bacteria to antibiotic...

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Literature Corpus work
864542ea-5355-537e-843e-020022ca9e92
DOI
10.1101/2020.10.21.20216853
Open publication

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Engineered phage endolysin eliminates <i>Gardnerella</i> in bacterial vaginosis without damaging the healthy vaginal microbiomeDOI 10.1101/2020.10.21.20216853
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