Article

Experimental evolution of phosphomannomutase-deficient yeast reveals compensatory mutations in a phosphoglucomutase

2022-04-08

Abstract excerpt

<h4>ABSTRACT</h4> The most common cause of human congenital disorders of glycosylation (CDG) are mutations in the phosphomannomutase gene PMM2 , which affect protein N -linked glycosylation. The yeast gene SEC53 encodes a nearly-identical homolog of human PMM2 . We evolved 384 populations of yeast harboring one of two human-disease-associated alleles, sec53 -V238M and sec53 -F126L, or wild-type SEC53 . We...

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Literature Corpus work: 859776f7-cd5d-5161-b07e-9204a055b84c
DOI: 10.1101/2022.04.06.487342

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